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Consider PPARs Treatment for Goiter

Updated: Jun 29, 2020

Is it common to be diagnosed with goiter? According to Medscape, It is estimated that goiters affect as many as 200 million of the 800 million people worldwide who have a diet deficient in iodine. Goiter is not fatal, and the symptoms might not get very serious. However, when the goiters are large, there might be some complications like fatigue, weight fluctuations, irritability and trouble sleeping due to difficulty to breathe.

There are different ways to treat goiter and PPAR is known to be one of the effective medications to treat goiter. If your goiter situation does not require surgery yet, you may be able to recover without surgery by treating it using PPAR. Hence, in this post, we will be discussing goiter and the effectiveness of PPAR in treating goiter.

Overview of this topic; treating goiter using PPARs:

1. What is Goiter?

2. What are the Symptoms and Causes of Goiter

3. How to Treat Goiter?

4. Considering PPARs for Goiter treatment without surgery

5. What is PPARs?

6. How does PPAR Treat Goiter?

7. Sources of Trusted PPAR Supplements


A goiter is an abnormal enlargement of thyroid gland or a “swollen” thyroid gland. A goiter will develop in anyone but it is more common among women. Risk factors of goiter also included: age over 40, smoking, pregnant or going through menopause. The lump will move up and down when you swallow.

Thyroid is a gland found in the neck just below the Adam’s apple. It is a butterfly-shaped gland.

The main function of thyroid is to produce T-4 and T-3, hormones which play a vital role in the body’s metabolism rate, heart and digestive functions, muscle control, and brain development. These 2 hormones control and maintain the metabolism rate, control the body temperature, regulates the production of proteins and they will influence the heart rate.

Besides, thyroid gland also produces Calcitonin which regulates calcium in the blood, plays a part in the maintenance of bones.

There are 2 main types of goiter:

- The entire thyroid gland swells and feels smooth to the touch.

- Solid or lumps which normally known as nodules develop in the thyroid gland and make the gland swells and feels lumpy to touch.

Having a goiter doesn't necessarily mean that your thyroid gland isn't working normally. Even when it's enlarged, your thyroid may produce normal amounts of hormones.

Symptoms and Causes of Goiter

Common symptoms of goiter included:

I. A swelling at the base of neck (can go to how big?)

II. A tight feeling in the throat

III. Coughing

IV. Hoarseness in voice

V. Difficulty in swallowing

VI. Difficulty in breathing

VII. Dizziness (When the arms are raised above the head)

One of the most common causes of goiter is a lack of iodine in the nutrients. Iodine is an essential mineral for the body to produce thyroid hormones. When the body doesn’t have enough iodine, the thyroid gland needs to work extra hard to produce sufficient thyroid hormone to support the body’s functions. In this way, it might exhaust the thyroid gland and hence causing the gland to grow larger.

Iodine deficiency may be worsened by a diet high in hormone-inhibiting foods like cabbage, broccoli and cauliflower.

Good food sources of iodine included seafoods (cod, tuna, seaweed, shrimp), grains like cereals and breads and dairy products like yogurt or cheese.

One could also suffer from goiter due to over- or underproduction of thyroid hormones in the gland. When the thyroid gland is producing too much thyroid hormones, it is known as Grave’s disease. This happens because the antibodies produced by the immune system mistakenly thought the thyroid gland is a threat and attack the healthy thyroid gland, triggering the thyroid gland to produce excessive hormones. The over stimulation of hormones causes the thyroid gland to swell.

Hashimoto’s disease is when the thyroid gland is not producing enough hormones, underactive thyroid. It is also due to autoimmune disorder like Grave’s disease.

When the hormone level is low, the pituitary gland will produce more thyroid stimulating hormones which as the result, causing the gland to swell.

When solid or fluid-filled lumps known as nodules are gathered in the thyroid gland, it might lead to swells in both sides of thyroid and hence causing the gland to enlarge, leading to Nodular Goiter.

Thyroid cancer might have the same symptom as nodular goiter where lumps are gathered in the gland. Biopsy of thyroid nodule will be conducted to accurately determine whether it’s cancerous.

Inflammation of gland, thyroiditis will cause pain and swelling in the thyroid too.

How to Treat Goiter?

Treatment depends on the size of the goiter, symptoms and the cause. Small goiters that aren't noticeable and don't cause problems usually don't need any treatment nor medications.

If the goiter is caused by thyroid hormones disorder, then medications will be provided. For hypothyroidism, thyroid hormone replacement will be given to resolve the symptoms of hypothyroidism and slowdown the release of thyroid-stimulating hormone from pituitary gland. And for hyperthyroidism, medications to normalize hormone levels will be given.

For inflammation in the thyroid gland, doctor may suggest aspirin or a corticosteroid medication to treat the inflammation. When the goiter is too large, surgery may be suggested to remove all or part of the thyroid gland. Surgery is also the treatment for thyroid cancer. There are some side effects like nausea and vomiting, difficulty in swallowing and stiffness, after removing the thyroid glands.

You may need to take levothyroxine after surgery, depending on the amount of thyroid removed.

In some cases, radioactive iodine is used to treat an overactive thyroid gland. The radioactive iodine is taken orally and reaches the thyroid gland through bloodstream, destroying the thyroid cells. The treatment results in a diminished size of the goiter, but eventually may also cause an underactive thyroid gland.

Radioactive iodine will be used to treat thyroid cancer too.

Why Consider PPARs for Goiter?

What is PPARs?

In the field of molecular biology, the Peroxisome Proliferator Activated Receptors (PPAR) is a group of nuclear receptor proteins that attach to the DNA to increase and regulate the expression of genes.

PPAR plays the role as a transcription factor that regulates the expression of genes, including the regulation of cellular differentiation, development and metabolism of body tissues.

The PPAR also acts on DNA response elements with the nuclear retinoic acid receptor. PPARs are involved in various independent and DNA-dependent molecular and enzymatic pathways in adipose tissue, liver, and skeletal muscles.

PPAR mainly exists in three subtypes or isoforms: the PPAR alpha, the PPAR gamma, and the PPAR beta/ delta.

The PPAR Alpha is widely expressed in body tissues. PPAR Alpha presents in the skeletal muscle, the liver and the heart which plays the crucial role to lower the triglyceride level and energy homeostasis. Activation of the PPAR alpha in the liver is beneficial in oxidation of fatty acid which will regulate energy for the peripheral tissues. The PPAR alpha is helpful in immune modulation and lowering triglyceride level. Despite, PPAR alpha also plays a crucial role in metabolism of lipid which is beneficial for the metabolic syndrome.

The PPAR beta/delta is active in many tissues and plays an important role to regulate the oxidation of fatty acids, ketone body synthesis and glucose sparing. PPAR beta/ delta presents markedly in brain, lungs, skeletal muscle and skin. Besides, PPAR beta/ delta is effective in inhibiting inflammatory mediators.

The PPAR gamma is ubiquitous. It presents in almost all tissues including heart, muscle, colon, kidney, pancreas and spleen. PPAR gamma promotes the triglyceride storage which is highly favourable for the regulation of lipid and glucose metabolism which is beneficial for chronic diseases. PPAR gamma is rich with anti-atherogenic and anti-inflammatory properties. PPAR gamma and its ligands are also the most critical one for the modulation of immune cells which boost our immunity.

How does PPAR Treat Goiter?

i. Anti-Inflammation

PPAR is rich in the anti-inflammation and block inflammation properties. PPAR gamma which is rich with anti-atherogenic and anti-inflammatory properties is often involved in the regulation of inflammation. PPAR modulates the body’s ability to regulate and decrease inflammation.

The PPAR is beneficial to reduce pain and inflammation and further prevent the production of various pro-inflammatory and angiogenic enzymes.

ii. Immunity

Activation of PPAR will enhance immunity cell proliferator capability which in other words, PPAR will boost our immunity. PPAR is effective to induce an immune profile similar to dominance of Th2 Cells. In terms of immunity, PPAR gamma and its ligands are indeed the most critical one for the modulation of immune cells like monocytes, T cells and NK cells and inflammatory reactions.

Besides, PPAR has also been recognized in contributing significantly in the immune response through its ability to avoid the expression of inflammatory cytokines and directing various immune cells toward anti-inflammatory phenotypes making PPAR to be effective in inhibiting inflammatory mediators.

On top of that, PPAR also plays the critical roles where it activates the cells functions and increase cells respondence by fuelling the cells to function properly. This is beneficial for the improvement of autoimmune disorder which attack the thyroid gland.

PPAR also increases Dendritic Cell Activity which help the immune system to identify “real threat” of the body and commands the immune system, the Natural Killer T Cells to quickly and clearly attack the threats. By fuelling the cells and boosting the immunity, PPAR helps the cells to target and fight the correct cells instead of attacking the healthy thyroid cells.

Beside activating the immune cells and anti-inflammatory properties, PPAR is beneficial in combating metabolic syndromes, immunology ailments and cancers too.

Check on this article 4 Benefits of taking PPARs Supplement to know more about the benefits of PPAR Supplement.

There are several simple and effective ways to increase and activate PPARs in our body. Maintaining healthy lifestyle which included regular exercises and balanced diets are one of the effective manners to increase and activate PPAR in our body.

Despite, there is a more effective and convenient way to increase PPAR in our body: taking PPAR Supplement.

Sources of Trusted PPAR Supplements

There are plenty of brands and suppliers offering PPAR Supplement in the market.

The Simply Nature PPARs appears to be one of the most recognized PPAR Supplements available in the market with plenty of testimonials and reviews from medical doctors and users. The Simply Nature PPARs are particularly popular among Singapore and Philippine users. Besides, Simply Nature PPARs is made up of 100% natural plant-based whole food which are totally free from additives, binder, fillers and any artificial substances which it would work in synergy with goiter medications or surgery (if any).

Another important benefit of Simply Nature PPARs is that it is available in several forms in order to meet the different needs of different people.

This is the most expensive Simply Nature PPARs products comparing to other Simply Nature PPARs Series products, but it is the most effective one as well. This is because each vial of liquid holds the amount of potency as high as 1,000 tablets. This PPARs Extract Liquid is meant for those with critical needs and anti-ageing purposes.

There are 6 liquid vials in a box of PPARs Extract Liquids.

Comparing to other consumable forms, a tablet or pill is always a more convenient and more portable form of supplements. The Simply Nature PPARs Plus Tablet contains almost 100 times more than normal vegetables of chlorophyll. Hence, it is beneficial too for the blood purification and anti-toxic process of the body. It is beneficial for constipation issues.

The tablets are chewable and there are 150 tablets for each bottle of PPARs Plus Tablet.

Comparing to conventional tablets, soft gel capsules are more easily to swallow and are more convenient to take comparing to liquid or powder. Furthermore, soft gel capsules are tasteless and do not have unpleasant “odour” of herbs.

30 capsules of soft gel PPARs concentrate extract in each pack of capsules.

Consuming PPAR in powder form will be a fast and effective way for the body to absorb the nutritional support. This is suitable for the people who had difficulty in swallowing capsule or tablets and people suffering with digestive problems. The Simply Nature PPARs Extract Powder is the most popular product among the Simply Nature PPARs Series. It is recommended for patients who are combatting serious illnesses.

The Simply Nature PPARs product series are not only sold through medical doctors, it is also available on the official Simply Nature Shopee and Lazada websites or the Simply Nature official website at

Be sure to check on the reviews and testimonials of products when purchasing any PPAR supplements. This is because, there are many other brands in the market which may contain side effects and this might put your body on irreversible health risks.


Anti-inflammatory property and immune boosting benefit of PPAR have made PPAR an effective supplement to treat goiter. Other than consuming medication and PPAR which help speed up the recovery process of goiter, it is also important to lead a healthy lifestyle and maintain a balanced and healthy diet. Should you have more questions about how PPAR can help your goiter condition, feel free to drop us an email or message on Facebook.

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